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Phenotypes Associated with This Genotype
Genotype
MGI:3617912
Allelic
Composition		 Tbx5tm1.1Jse/Tbx5+
Genetic
Background		 involves: Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx5tm1.1Jse mutation (0 available); any Tbx5 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal digit morphology ( J:105332 )
• forelimb digit 1 elements are significantly longer than in wild-type mice

cardiovascular system
abnormal heart morphology ( J:105332 )
• the severity of congenital heart defects is less than in mice that are also heterozygous for Sall4 and after 15 generations of out breeding to Black Swiss no ventricular septal defects are seen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory