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Phenotypes Associated with This Genotype
Genotype
MGI:3617533
Allelic
Composition
Ciitatm1Ccum/Ciitatm1Ccum
Genetic
Background
NOD.129S2(B6)-Ciitatm1Ccum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ciitatm1Ccum mutation (4 available); any Ciita mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• on the NOD background, by 35 weeks of age and later, no mutants show hyperglycemia while 40% of NOD-sufficient mice develop diabetes by 35 weeks of age (J:106081)
• on the NOD background, by 35 weeks of age and later, no mutants show hyperglycemia while 40% of NOD-sufficient mice develop diabetes by 35 weeks of age (J:106081)

immune system
• a 10-fold reduction in levels of peripheral CD4+ T cells is observed compared to controls (J:106081)
• a 10-fold reduction in levels of peripheral CD4+ T cells is observed compared to controls (J:106081)
• CD8+ T cells are slightly over-represented in mutants (25%) compared to controls (16%) (J:106081)
• CD8+ T cells are slightly over-represented in mutants (25%) compared to controls (16%) (J:106081)
• MHC class II molecule expression is almost completely absent from spleen cells (J:106081)
• MHC class II molecule expression is almost completely absent from spleen cells (J:106081)
• mice do not develop diabetes (2 consecutive blood glucose measures >16.5 nM) up to 30 weeks of age (J:107051)
• mice do not develop diabetes (2 consecutive blood glucose measures >16.5 nM) up to 30 weeks of age (J:107051)
• female mutants show pancreatic infiltration by 15 weeks of age (J:106081)
• female mutants show pancreatic infiltration by 15 weeks of age (J:106081)
• when recovered from NOD diabetic female recipients, islet grafts obtained from these class II-deficient NOD mice show severe infiltration and lack almost all insulin production (J:107051)
• when recovered from NOD diabetic female recipients, islet grafts obtained from these class II-deficient NOD mice show severe infiltration and lack almost all insulin production (J:107051)
• at 15 weeks of age, around 2% of islets in female mutants show perinsulitis or insulitis compared with 75% in pre-diabetic and diabetic mice (J:106081)
• at 15 weeks of age, around 2% of islets in female mutants show perinsulitis or insulitis compared with 75% in pre-diabetic and diabetic mice (J:106081)

hematopoietic system
• a 10-fold reduction in levels of peripheral CD4+ T cells is observed compared to controls (J:106081)
• a 10-fold reduction in levels of peripheral CD4+ T cells is observed compared to controls (J:106081)
• CD8+ T cells are slightly over-represented in mutants (25%) compared to controls (16%) (J:106081)
• CD8+ T cells are slightly over-represented in mutants (25%) compared to controls (16%) (J:106081)
• MHC class II molecule expression is almost completely absent from spleen cells (J:106081)
• MHC class II molecule expression is almost completely absent from spleen cells (J:106081)

endocrine/exocrine glands
• female mutants show pancreatic infiltration by 15 weeks of age (J:106081)
• female mutants show pancreatic infiltration by 15 weeks of age (J:106081)
• when recovered from NOD diabetic female recipients, islet grafts obtained from these class II-deficient NOD mice show severe infiltration and lack almost all insulin production (J:107051)
• when recovered from NOD diabetic female recipients, islet grafts obtained from these class II-deficient NOD mice show severe infiltration and lack almost all insulin production (J:107051)
• at 15 weeks of age, around 2% of islets in female mutants show perinsulitis or insulitis compared with 75% in pre-diabetic and diabetic mice (J:106081)
• at 15 weeks of age, around 2% of islets in female mutants show perinsulitis or insulitis compared with 75% in pre-diabetic and diabetic mice (J:106081)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:106081


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory