Mouse Genome Informatics
hm
    Ciitatm1Ccum/Ciitatm1Ccum
NOD.129S2(B6)-Ciitatm1Ccum
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• on the NOD background, by 35 weeks of age and later, no mutants show hyperglycemia while 40% of NOD-sufficient mice develop diabetes by 35 weeks of age

immune system
• a 10-fold reduction in levels of peripheral CD4+ T cells is observed compared to controls
• CD8+ T cells are slightly over-represented in mutants (25%) compared to controls (16%)
• MHC class II molecule expression is almost completely absent from spleen cells
• mice do not develop diabetes (2 consecutive blood glucose measures >16.5 nM) up to 30 weeks of age
• female mutants show pancreatic infiltration by 15 weeks of age
• when recovered from NOD diabetic female recipients, islet grafts obtained from these class II-deficient NOD mice show severe infiltration and lack almost all insulin production
• at 15 weeks of age, around 2% of islets in female mutants show perinsulitis or insulitis compared with 75% in pre-diabetic and diabetic mice

hematopoietic system
• a 10-fold reduction in levels of peripheral CD4+ T cells is observed compared to controls
• CD8+ T cells are slightly over-represented in mutants (25%) compared to controls (16%)
• MHC class II molecule expression is almost completely absent from spleen cells

endocrine/exocrine glands
• female mutants show pancreatic infiltration by 15 weeks of age
• when recovered from NOD diabetic female recipients, islet grafts obtained from these class II-deficient NOD mice show severe infiltration and lack almost all insulin production
• at 15 weeks of age, around 2% of islets in female mutants show perinsulitis or insulitis compared with 75% in pre-diabetic and diabetic mice

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:106081