Mouse Genome Informatics
ht
    Pkd1tm2Jzh/Pkd1+
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
renal/urinary system
• microscopic kidney cysts are seen as early as 2.5 months of age, much earlier than in heterozygous Pkd1tm1Jzh mice
• 70% or 2.5-14.5 month old mice have 2-30 cysts

liver/biliary system
• 48% develop visible liver cysts that are first observed at 11 months of age and all have cysts at later stages (18-24 months)

endocrine/exocrine glands
• 1 of 21 mice develop a pancreatic cyst at 14.5 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease 1; PKD1 173900 J:72627