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Phenotypes Associated with This Genotype
Genotype
MGI:3617439
Allelic
Composition
Hgdaku/Hgdaku
Genetic
Background
either: (involves: 129/Sv * BALB/cByJ * NB) or (involves: 129/Sv * C57BL/6J * NB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgdaku mutation (1 available); any Hgd mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• high levels of homogenistic acid
• urine gradually turns dark over several days
• causes darkening of bedding
• ochronosis which is typical of alkaptonuria in humans does not occur in mice

skeleton
N
• arthritis which is typical of alkaptonuria in humans does not occur in mice

renal/urinary system
• high levels of homogenistic acid
• urine gradually turns dark over several days
• causes darkening of bedding
• ochronosis which is typical of alkaptonuria in humans does not occur in mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alkaptonuria; AKU 203500 J:16506


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory