Phenotypes Associated with This Genotype

Genotype
MGI:3617383

• Allelic Composition: Ercc1^tm1Dwm/Ercc1^tm1Dwm
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:15422 )

• died before weaning of liver failure

liver/biliary system

liver degeneration ( J:15422 )

• evidenced by a 15-fold increase in alanine aminotransferase activity

decreased liver function ( J:15422 )

• evidenced by a 2-fold increase in alkaline phosphatase levels and 7-fold increase in bilirubin

cellular

abnormal cell nucleus morphology ( J:15422 )

• liver cells showed variation in nuclear size

aneuploidy ( J:15422 )

• severe aneuploidy seen in liver cells by 3 weeks of age

polyploidy ( J:15422 )

• perinatal liver cells showed varying degrees of polyploidy

growth/size/body

decreased birth body size ( J:15422 )

• runted at birth