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Phenotypes Associated with This Genotype
Genotype
MGI:3615834
Allelic
Composition
Nbntm1Jpt/Nbntm1Jpt
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm1Jpt mutation (1 available); any Nbn mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• mice exhibit normal ionizing radiation-induced apoptosis in the developing nervous system and cultured thymocytes
• MEFs exhibit defective intra S phase and G2/M checkpoints after ionizing radiation treatment
• MEFs exhibit pronounced sensitivity to ionizing radiation
• significantly higher levels of chromosomal aberrations following ionizing radiation treatment than wild-type, exhibiting increases in both deletion and exchange type aberrations

immune system
N
• immunoglobulin isotype profiles are indistinguishable from controls and splenic B and thymic T cell propulations vary by less than 25% from wild-type

reproductive system
N
• male and females are fertile and exhibit no abnormalities in ovaries or testes

neoplasm
N
• homozygotes are not markedly prone to malignancy

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Nijmegen breakage syndrome DOID:7400 OMIM:251260
J:75956


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory