Phenotypes Associated with This Genotype

Genotype
MGI:3615623

• Allelic Composition: Casp8^tm1Syon/Casp8^tm1Syon; Tg(Myh7-BVp35-EGFP)#Ksa/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:102279 )

• mutant embryos with transgene expression could not survive to E12.5 of development

cardiovascular system

cardiovascular system phenotype ( J:102279 )

N • mutant embryos expressing the transgene underwent normal trabeculae formation, whereas trabeculae degeneration occurred in homozygous mutant without the transgene expression

abnormal vitelline vasculature morphology ( J:102279 )

• irregular yolk sac angiogenesis is observed

hemopericardium ( J:102279 )

• at stage E10.5, most (74%) of the mutant embryos expressing the transgene did not show hemorrhage

• the majority of mutant embryos without the transgene expression had hemorrhage at stage E10.5

• mutant embryos exhibited hemorrhage in the pericardial cavity when they further developed from E10.5 to E11.0- E11.5

increased cardiomyocyte apoptosis ( J:102279 )

• in E11.0-11.5 mutant embryos, TUNEL-positive cells localized to the compact area, but not trabeculae of the ventricle were detected

muscle

increased cardiomyocyte apoptosis ( J:102279 )

• in E11.0-11.5 mutant embryos, TUNEL-positive cells localized to the compact area, but not trabeculae of the ventricle were detected

embryo

abnormal vitelline vasculature morphology ( J:102279 )

• irregular yolk sac angiogenesis is observed

abnormal neural tube morphology ( J:102279 )

• aberrant neural tube development is observed

nervous system

abnormal neural tube morphology ( J:102279 )

• aberrant neural tube development is observed

homeostasis/metabolism

hemopericardium ( J:102279 )

• at stage E10.5, most (74%) of the mutant embryos expressing the transgene did not show hemorrhage

• the majority of mutant embryos without the transgene expression had hemorrhage at stage E10.5

• mutant embryos exhibited hemorrhage in the pericardial cavity when they further developed from E10.5 to E11.0- E11.5

cellular

increased cardiomyocyte apoptosis ( J:102279 )

• in E11.0-11.5 mutant embryos, TUNEL-positive cells localized to the compact area, but not trabeculae of the ventricle were detected