Phenotypes Associated with This Genotype

Genotype
MGI:3615465

• Allelic Composition: Zap70^mur/Zap70^mur
• Genetic Background: C57BL/6Apb-Zap70^mur/ApbH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell number ( J:104190 )

• homozygous mutant mice have reduced numbers of naive CD4⁺ CD8^- and CD4^- CD8⁺ (SP) T cells

• homozygous mutant mice have an overall deficiency in numbers of CD4⁺ SP cells

increased IgG2b level ( J:104190 )

• serum IgG2b levels are elevated in mutant mice

abnormal T cell physiology ( J:104190 )

• a cell-intrinsic defect in T cell receptor signal transduction is demonstrated by a mild-to-moderate impairment in the response of homozygous mutant mice to anti-T cell receptor stimulation

abnormal T cell activation ( J:104190 )

• naive CD4⁺ CD8^- and CD4^- CD8⁺ (SP) T cells of homozygous mutants are hyperactivated

hematopoietic system

decreased T cell number ( J:104190 )

• homozygous mutant mice have reduced numbers of naive CD4⁺ CD8^- and CD4^- CD8⁺ (SP) T cells

• homozygous mutant mice have an overall deficiency in numbers of CD4⁺ SP cells

increased IgG2b level ( J:104190 )

• serum IgG2b levels are elevated in mutant mice

abnormal T cell physiology ( J:104190 )

• a cell-intrinsic defect in T cell receptor signal transduction is demonstrated by a mild-to-moderate impairment in the response of homozygous mutant mice to anti-T cell receptor stimulation

abnormal T cell activation ( J:104190 )

• naive CD4⁺ CD8^- and CD4^- CD8⁺ (SP) T cells of homozygous mutants are hyperactivated