About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3615049
Allelic
Composition
Spta1ihj/Spta1ihj
Genetic
Background
involves: HRS/J * LAH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spta1ihj mutation (1 available); any Spta1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most affected mice die during the first week of life; of those surviving the first week, many die after weaning (J:105409)
• most affected mice die during the first week of life; of those surviving the first week, many die after weaning (J:105409)

liver/biliary system
• some homozygous mice exhibit enlargement of the liver (J:105409)
• some homozygous mice exhibit enlargement of the liver (J:105409)
• by the second postnatal day, homozygous mutants can be identified by their pale orange color; the orange pallor of their skin, nails and mucosa persists throughout life (J:105409)
• by the second postnatal day, homozygous mutants can be identified by their pale orange color; the orange pallor of their skin, nails and mucosa persists throughout life (J:105409)

growth/size/body
• homozygous mutant mice are much smaller than their littermates (J:105409)
• homozygous mutant mice are much smaller than their littermates (J:105409)

reproductive system
• in the rare instance that a homozygous female becomes pregnant, she is likely to die giving birth (J:105409)
• in the rare instance that a homozygous female becomes pregnant, most of the pups are stillborn or die soon after birth (J:105409)
• in the rare instance that a homozygous female becomes pregnant, she is likely to die giving birth (J:105409)
• in the rare instance that a homozygous female becomes pregnant, most of the pups are stillborn or die soon after birth (J:105409)

behavior/neurological
• in the rare instance that a homozygous female becomes pregnant, if the mother and any pups survive, the dam will abandon her offspring (J:105409)
• in the rare instance that a homozygous female becomes pregnant, if the mother and any pups survive, the dam will abandon her offspring (J:105409)

digestive/alimentary system
• feces of mutant mice are orange colored and soft (J:105409)
• feces of mutant mice are orange colored and soft (J:105409)

hematopoietic system
• in homozygous mice, the normal nodular splenic architecture is absent (J:105409)
• in homozygous mice, the normal nodular splenic architecture is absent (J:105409)
• the spleens of homozygous mice, while of normal size for about 3 days after birth, become hypertrophied and in adults are threefold heavier than those of unaffected mice (J:105409)
• the spleens of homozygous mice, while of normal size for about 3 days after birth, become hypertrophied and in adults are threefold heavier than those of unaffected mice (J:105409)

immune system
• in homozygous mice, the normal nodular splenic architecture is absent (J:105409)
• in homozygous mice, the normal nodular splenic architecture is absent (J:105409)
• the spleens of homozygous mice, while of normal size for about 3 days after birth, become hypertrophied and in adults are threefold heavier than those of unaffected mice (J:105409)
• the spleens of homozygous mice, while of normal size for about 3 days after birth, become hypertrophied and in adults are threefold heavier than those of unaffected mice (J:105409)

homeostasis/metabolism
• the circulating bilirubin level of affected mice is elevated, indicating red cell lysis (J:105409)
• the circulating bilirubin level of affected mice is elevated, indicating red cell lysis (J:105409)

integument
• development of the hair coat occurs 4-5 days later in homozygotes than in their littermates (J:105409)
• development of the hair coat occurs 4-5 days later in homozygotes than in their littermates (J:105409)
• by the second postnatal day, homozygous mutants can be identified by their pale orange color; the orange pallor of their skin, nails and mucosa persists throughout life (J:105409)
• by the second postnatal day, homozygous mutants can be identified by their pale orange color; the orange pallor of their skin, nails and mucosa persists throughout life (J:105409)

Mouse Models of Human Disease
OMIM ID Ref(s)
Spherocytosis, Type 3; SPH3 270970 J:157766


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory