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Phenotypes Associated with This Genotype
Genotype
MGI:3614634
Allelic
Composition
Abca1tm2Jp/Abca1tm2Jp
Tg(APOA1)427Bres/?
Genetic
Background
involves: 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm2Jp mutation (1 available); any Abca1 mutation (9 available)
Tg(APOA1)427Bres mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• significantly reduced total plasma cholesterol (J:104719)
• significantly reduced free cholesterol (J:104719)
• significantly reduced levels of esterified cholesterol (J:104719)
• significantly reduced total plasma cholesterol (J:104719)
• significantly reduced free cholesterol (J:104719)
• significantly reduced levels of esterified cholesterol (J:104719)
• significantly reduced HDL cholesterol (J:104719)
• lower than in absence of transgene (J:104719)
• faster plasma HDL catabolism (J:104719)
• significantly reduced HDL cholesterol (J:104719)
• lower than in absence of transgene (J:104719)
• faster plasma HDL catabolism (J:104719)
• significantly reduced phospolipid levels (J:104719)
• significantly reduced phospolipid levels (J:104719)
• human apoA-I not detectable in plasma (J:104719)
• human apoA-I not detectable in plasma (J:104719)

renal/urinary system
• two fold increase in HDL catabolism in the kidney (J:104719)
• two fold increase in HDL catabolism in the kidney (J:104719)

Mouse Models of Human Disease
OMIM ID Ref(s)
Tangier Disease; TGD 205400 J:104719


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory