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Phenotypes Associated with This Genotype
Genotype
MGI:3614342
Allelic
Composition
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
Genetic
Background
FVB/N-Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance
• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors
• the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250
• female specific phenotype, global induction of extremely cystic and dilated mammary epithelial hyperplasia without defined alveolar structures in 12-week-old virgin animals
• the mammary epithelium were incapable of nursing
• mammary epithelial hyperplasias displayed extensive apoptotic cell death

neoplasm
• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance
• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors
• the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250

integument
• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance
• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors
• the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250
• female specific phenotype, global induction of extremely cystic and dilated mammary epithelial hyperplasia without defined alveolar structures in 12-week-old virgin animals
• the mammary epithelium were incapable of nursing
• mammary epithelial hyperplasias displayed extensive apoptotic cell death

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:56327


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory