Mouse Genome Informatics
tg
    Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
FVB/N-Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• female specific phenotype, global induction of extremely cystic and dilated mammary epithelial hyperplasia without defined alveolar structures in 12-week-old virgin animals (J:56327)
• the mammary epithelium were incapable of nursing (J:56327)

cellular
• mammary epithelial hyperplasias displayed extensive apoptotic cell death

tumorigenesis
• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance
• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors
• the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250

integument
• female specific phenotype, global induction of extremely cystic and dilated mammary epithelial hyperplasia without defined alveolar structures in 12-week-old virgin animals (J:56327)
• the mammary epithelium were incapable of nursing (J:56327)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:56327