Phenotypes Associated with This Genotype

Genotype
MGI:3613459

• Allelic Composition: Dio1^tm1Vag/Dio1^tm1Vag
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:104508 )

• male body weight at 6-19 weeks of age, but not at 4 weeks of age, is 5-11% greater than in wild-type

homeostasis/metabolism

decreased circulating cholesterol level ( J:104508 )

• induction of hyperthyroidism by administration of a daily injection of T3 results in a greater decrease in serum cholesterol levels than in controls

abnormal thyroid hormone level ( J:104508 )

increased thyroxine level ( J:104508 )

• significant increase in T4 levels in the thyroids of euthyroid mice

increased circulating thyroxine level ( J:104508 )

increased triiodothyronine level ( J:104508 )

• significant increase in T3 levels in the thyroids of euthyroid mice

increased circulating triiodothyronine level ( J:104508 )

• elevation in serum reverse T3 (3,3',5'-triiodothyronine) levels but not T3 (3,5,3'-triiodothyronine) or thyroid-stimulating hormone (TSH) and no evidence of peripheral hypothyroidism

abnormal urine homeostasis ( J:104508 )

• urinary excretion of [¹²⁵I] iodide is markedly diminished after injection of radiolabeled T4 or T3 (for T4, 10% vs. 40% in controls; for T3, 10% vs. 45% in controls)

abnormal response/metabolism to endogenous compounds ( J:104508 )

• induction of hyperthyroidism by administration of a daily injection of T3 results in a greater decrease in serum cholesterol levels and a larger increase in the heart weight/body weight ratio than in controls

digestive/alimentary system

abnormal feces composition ( J:104508 )

• fecal excretion of endogenous iodothyronines is greatly increased, with a 2- and 3-fold increase in T4 and T3, respectively, and a 5-fold increase in rT3 and 3,3-T2

• fecal excretion of [¹²⁵I] iodothyronines is greatly increased after injection of radiolabeled T4 or T3 (for T4, 70% vs. 42% in controls; for T3, 80% vs. 45% in controls)

renal/urinary system

abnormal urine homeostasis ( J:104508 )

• urinary excretion of [¹²⁵I] iodide is markedly diminished after injection of radiolabeled T4 or T3 (for T4, 10% vs. 40% in controls; for T3, 10% vs. 45% in controls)

endocrine/exocrine glands

abnormal thyroid gland physiology ( J:104508 )

• induction of hyperthyroidism by administration of a daily injection of T3 results in a greater degree of tissue hyperthyroidism than in wild-type