Phenotypes Associated with This Genotype

Genotype
MGI:3613060

• Allelic Composition: Gt(ROSA)26Sor^{tm1(sb11)Njen}/Gt(ROSA)26Sor⁺; TgTn(sb-T2/Onc2)6070Njen/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:102234 )

• all mice that survive past weaning die by 17 weeks of age from cancer

lethality throughout fetal growth and development, incomplete penetrance ( J:102234 )

• only 12.5% (17 of 136) of pups at birth are double mutants and significant loss of these mice is seen at E16 but not at E10

neoplasm

increased tumor incidence ( J:102234 )

• all double mutants develop cancer with a variety of tumor types

increased lymphoma incidence ( J:102234 )

• non-T/non-B cell derived lymphoma is also seen

increased T cell derived lymphoma incidence ( J:102234 )

• most common type of tumor

increased B cell derived lymphoma incidence ( J:102234 )

increased medulloblastoma incidence ( J:102234 )

• some mice develop medulloblastomas

embryo

decreased embryo size ( J:102234 )

• at E10 and E16, many embryos appear smaller than control littermates

digestive/alimentary system

abnormal duodenum morphology ( J:102234 )

• hyperplasia of the duodenum was seen in 2 mice

growth/size/body

decreased embryo size ( J:102234 )

• at E10 and E16, many embryos appear smaller than control littermates

decreased fetal size ( J:102234 )

• at E16

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:102234 )

• most common type of tumor

nervous system

increased medulloblastoma incidence ( J:102234 )

• some mice develop medulloblastomas