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Phenotypes Associated with This Genotype
Genotype
MGI:3612482
Allelic
Composition
Fscn2tm2Sykk/Fscn2+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fscn2tm2Sykk mutation (0 available); any Fscn2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• shorter outer segments than in wild-type at 4 and 24 weeks of age
• thinner inner nuclear layer with reduced cell counts than in wild-type at 24 weeks of age
• thinner outer nuclear layer with reduced cell counts than in wild-type at 4 and 24 weeks of age
• decrease in rod function that worsens with increasing age and is followed by a reduction of cone function
• photopic b-waves are smaller than in wild-type at later ages (24-32 weeks) but not at early ages (4 weeks)
• photopic b-wave amplitudes decrease much later than the decrease in the scotopic b-wave amplitudes
• scotopic a- and b-waves are smaller than in wild-type at later ages (24-32 weeks) but not at early ages (4 weeks)

nervous system
• shorter outer segments than in wild-type at 4 and 24 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinitis Pigmentosa 30; RP30 607921 J:103713


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory