Phenotypes for S1pr1 MGI:3611330 MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:189010 )

• rapid demise and synchronous death of the embryos between E13.5 and E14

• glomeruloid lesions are also seen on the femoral, tail, and intercostal arteries

• glomeruloid lesions contain abundant mural cells and basement membrane proteins

• abnormal microvasculature around the aorta that forms glomeruloid lesions with numerous ectopic endothelium-lined connections to the aortic lumen

• at E11.5 lesions are mainly concentrated on the dorsal side of the aorta, by E12.5 lesions often occur in lateral regions as well, and by E13.5 lesions frequently surround the aortic circumference

abnormal aorta endothelium morphology ( J:189010 )

• massive endothelial hyperplasia

abnormal aorta smooth muscle morphology ( J:189010 )

• coverage of the aorta is abnormal

abnormal vascular branching morphogenesis ( J:189010 )

• increase in the number of endothelial tip cells, protrusions of endothelial filopodia, and overall vascular density (endothelial hyper-sprouting) is detected from E11.5 onward in the hindbrain, neural tube and limb vasculature

hemorrhage ( J:103755 )

increased vascular endothelial cell apoptosis ( J:189010 )

• at E13.5 massive induction of apoptosis is seen in endothelial cells

increased neuron apoptosis ( J:189010 )

• at E13.5 massive induction of apoptosis is seen in the dorsal root ganglia

abnormal forebrain morphology ( J:103755 )

• massive cell loss in the forebrain at E12.5

abnormal diencephalon morphology ( J:103755 )

• increase in apoptotic cells in the neuroepithelial layers of the diencephalons at E12.5

abnormal telencephalon morphology ( J:103755 )

• increase in apoptotic cells in the neuroepithelial layers of the telencephalon and a decrease in mitotic cell numbers at E12.5

abnormal NK cell differentiation ( J:154069 )

• in reconstitution experiments, derived NK cells accumulate in the lymph nodes and bone marrow indicating a reduction in NK cell egression from the lymph nodes and bone marrow compared to when wild-type bone marrow is used

• egression of NK cells from the bone marrow into the bone marrow sinusoids is impaired compared to in wild-type mice

decreased NK cell number ( J:154069 )

• in the bone marrow sinusoids