embryo
• at E8.0, heterozygotes exhibit a delay in chorioallantoic fusion; however, all heterozygous embryos undergo chorioallantoic fusion past the 8-somite stage and appear indistinguishable from wild-type embryos
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• at the 4- to 5-somite stage, heterozygotes display a lag in allantois development relative to somite-matched wild-type embryos dissected at E8.0
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