Phenotypes for Nkx2-2 Nkx6-1 MGI:3608712 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nkx2-2^tm1Jlr/Nkx2-2^tm1Jlr Nkx6-1^tm1Jlr/Nkx6-1^tm1Jlr
Genetic Background	involves: 129 * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-2^tm1Jlr mutation (0 available); any Nkx2-2 mutation (14 available)
Nkx6-1^tm1Jlr mutation (0 available); any Nkx6-1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased PP cell number ( J:65594 )

• double homozygotes show a reduction in pancreatic polypeptide-expressing cells that is comparable to that observed in single Nkx2-2^tm1Jlr homozygotes

decreased pancreatic alpha cell number ( J:65594 )

• double homozygotes show a reduction in glucagon-expressing cells that is comparable to that observed in single Nkx2-2^tm1Jlr homozygotes

decreased pancreatic beta cell number ( J:65594 )

• double homozygotes accumulate incompletely differentiated islet cells, exhibing a pancreatic phenotype that is identical to that observed in single Nkx2-2^tm1Jlr homozygotes, indicating that Nkx6-1 lies downstream of Nkx2-2 in the major pathway of beta-cell formation

disorganized pancreatic islets ( J:65594 )

• double homozygotes exhibit a disrupted islet architecture, similar to that observed in single Nkx2-2^tm1Jlr homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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