Phenotypes Associated with This Genotype

Genotype
MGI:3608055

• Allelic Composition: Rps6^tm1Om/Rps6^tm1Om
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:100952 )

• MEFs are 24% smaller than in wild-type due to impaired growth but not accelerated cell division

abnormal cell physiology ( J:100952 )

• MEFs accumulate proteins 1.4-fold faster than in wild-type, have a significantly shorter population doubling time, and exhibit a 14% decrease in the half-transit time of ribosomes

abnormal cell cycle ( J:100952 )

• decrease in the percentage of MEFs in G1 phase, reflecting a shortening of G1 from 16.4 hours in wild-type to 8.2 hours in mutant MEFs

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:100952 )

• greater density of cells in islets

abnormal pancreatic beta cell morphology ( J:100952 )

• beta cells are reduced in size, however total beta cell mass is similar to wild-type and acinar cells and T lymphocytes are normal size

decreased insulin secretion ( J:100952 )

• 2-fold decrease in total pancreatic insulin content

homeostasis/metabolism

decreased insulin secretion ( J:100952 )

• 2-fold decrease in total pancreatic insulin content

decreased circulating insulin level ( J:100952 )

• 2-fold reduction in insulin levels during a fasting state

impaired glucose tolerance ( J:100952 )

• exhibit a higher and prolonged hyperglycemic response following glucose challenge

increased insulin sensitivity ( J:100952 )

• increased insulin sensitivity in peripheral tissues

liver/biliary system

abnormal hepatocyte morphology ( J:100952 )

• IL-7 dependent cells from E14 livers are 19% smaller than in wild-type, however newborn weight is normal