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Phenotypes Associated with This Genotype
Genotype
MGI:3607781
Allelic
Composition
Ndntm1Ky/Ndn+
Genetic
Background
involves: C57BL/6 * CBA * ICR/Slc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndntm1Ky mutation (1 available); any Ndn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at P14 and P29 in mice with a paternally inherited allele, latencies in the hotplate and tail-flick test are about 2-fold greater than those of wild-type mice; however, no postnatal lethality is seen when this allele is paternally inherited on an ICR background (J:100024)
• at P14 and P29 in mice with a paternally inherited allele, latencies in the hotplate and tail-flick test are about 2-fold greater than those of wild-type mice; however, no postnatal lethality is seen when this allele is paternally inherited on an ICR background (J:100024)

nervous system
• when this allele is paternally inherited a 1.6- to 1.8-fold increase in apoptosis is seen in the cervical dorsal root ganglia at E12.5 (J:100024)
• the density of nociceptive neurons (substance P-containing) is reduced to 59% that in wild-type mice at P0 (J:100024)
• at P0 the total neuron number is reduced to 88% that in wild-type mice (J:100024)
• when this allele is paternally inherited a 1.6- to 1.8-fold increase in apoptosis is seen in the cervical dorsal root ganglia at E12.5 (J:100024)
• the density of nociceptive neurons (substance P-containing) is reduced to 59% that in wild-type mice at P0 (J:100024)
• at P0 the total neuron number is reduced to 88% that in wild-type mice (J:100024)

cellular

integument
• at P14 and P29 in mice with a paternally inherited allele, latencies in the hotplate and tail-flick test are about 2-fold greater than those of wild-type mice; however, no postnatal lethality is seen when this allele is paternally inherited on an ICR background (J:100024)
• at P14 and P29 in mice with a paternally inherited allele, latencies in the hotplate and tail-flick test are about 2-fold greater than those of wild-type mice; however, no postnatal lethality is seen when this allele is paternally inherited on an ICR background (J:100024)

Mouse Models of Human Disease
OMIM ID Ref(s)
Prader-Willi Syndrome; PWS 176270 J:100024


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory