Mouse Genome Informatics
ht
    Ndntm1Ky/Ndn+
involves: C57BL/6 * CBA * ICR/Slc
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• at P14 and P29 in mice with a paternally inherited allele, latencies in the hotplate and tail-flick test are about 2-fold greater than those of wild-type mice; however, no postnatal lethality is seen when this allele is paternally inherited on an ICR background

nervous system
• when this allele is paternally inherited a 1.6- to 1.8-fold increase in apoptosis is seen in the cervical dorsal root ganglia at E12.5
• the density of nociceptive neurons (substance P-containing) is reduced to 59% that in wild-type mice at P0
• at P0 the total neuron number is reduced to 88% that in wild-type mice

cellular

integument
• at P14 and P29 in mice with a paternally inherited allele, latencies in the hotplate and tail-flick test are about 2-fold greater than those of wild-type mice; however, no postnatal lethality is seen when this allele is paternally inherited on an ICR background

Mouse Models of Human Disease
OMIM IDRef(s)
Prader-Willi Syndrome; PWS 176270 J:100024