About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3606862
Allelic
Composition		 Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Tg(KRT14-cre/ERT2)1Ipc/?
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (110 available)
Tg(KRT14-cre/ERT2)1Ipc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired skin barrier function ( J:101729 )
• regardless of when tamoxifen induction occurred
• very severely affected

integument
impaired skin barrier function ( J:101729 )
• regardless of when tamoxifen induction occurred
• very severely affected
abnormal skin morphology ( J:101729 )
• regardless of when tamoxifen induction occurred
abnormal epidermis stratum corneum morphology ( J:101729 )
• only 1-2 cornified cell layers present
abnormal epidermis stratum granulosum morphology ( J:101729 )
• swollen cytoplasm and nuclei
enlarged spinous cells ( J:101729 )
• swollen cytoplasm and nuclei

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory