About   Help   FAQ
Phenotypes Associated with This Genotype
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
• in histologic sections of eyes from E15 homozygous transgenic embryos, the lens epithelium appears thickened
• histologic examination of the lenses of homozygous transgenic mice at embryonic days E15 and E19 and at postnatal day P18 reveals gross disorganization of the secondary fibers
• homozygous transgenic mice have severe, total bilateral cataracts
• in histologic sections of eyes from E15 homozygous embryos, disorganization of the lens bow region is apparent; sections of E19 transgenic eyes show more rapid progression of the abnormality in homozygous than in heterozygous animals
• upon histologic examination of the eyes, the lenses of homozygous transgenic mice are obviously smaller than those of heterozygous transgenic or wildtype mice, approximately the size of the nuclei of the latter animals' lenses; this difference is apparent by embryonic day E15 and remains obvious
• homozygous transgenic mice present with severe, grossly obvious microphthalmia; their eyes weigh on average 63% less than those of wildtype littermates at 20 days of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract 19 multiple types DOID:0110263 OMIM:615277

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory