Mouse Genome Informatics
involves: C57BL/6 * SJL
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• in histologic sections of eyes from E15 homozygous transgenic embryos, the lens epithelium appears thickened
• histologic examination of the lenses of homozygous transgenic mice at embryonic days E15 and E19 and at postnatal day P18 reveals gross disorganization of the secondary fibers
• homozygous transgenic mice have severe, total bilateral cataracts
• in histologic sections of eyes from E15 homozygous embryos, disorganization of the lens bow region is apparent; sections of E19 transgenic eyes show more rapid progression of the abnormality in homozygous than in heterozygous animals
• upon histologic examination of the eyes, the lenses of homozygous transgenic mice are obviously smaller than those of heterozygous transgenic or wildtype mice, approximately the size of the nuclei of the latter animals' lenses; this difference is apparent by embryonic day E15 and remains obvious
• homozygous transgenic mice present with severe, grossly obvious microphthalmia; their eyes weigh on average 63% less than those of wildtype littermates at 20 days of age

Mouse Models of Human Disease
Cataract 19; CTRCT19 615277 J:100078