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Phenotypes Associated with This Genotype
Genotype
MGI:3606464
Allelic
Composition
Acvrl1tm1Dgen/Acvrl1tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvrl1tm1Dgen mutation (1 available); any Acvrl1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal cardiac morphology, pericardial effusion, and growth retardation in Tmem100tm1.1Ysai and Acvrl1tm1Dgen homozygotes

mortality/aging
• embryonic death between E9.5 and E10.5 (J:101679)
• homozygotes found at E10.5 were resorbing (J:101679)
• die around E10.5 - E11.0 (J:186473)

cardiovascular system
• at E9.5, paired dorsal aortas show marked dilation and narrowing with clumps of blood cells frequently seen in the caudal region
• expression analysis indicates defects in arterial differentiation and maturation
• mural layers surrounding the aorta are thinner at E9.5
• coarse vascular patterns indicative of impaired remodeling are seen at E9.5
• absence of large vessels at E10.5
• dilation of vessels
• mural layers surrounding the myocardium are thinner at E9.5
• poorly formed at E9.5
• at E9.5
• massive pericardial effusion at E10.5

embryo
• absence of large vessels at E10.5
• dilation of vessels
• detachment of endodermal and mesodermal layers at E9.5
• coarse vascular patterns indicative of impaired remodeling are seen at E9.5

growth/size/body

homeostasis/metabolism
• massive pericardial effusion at E10.5

muscle
• poorly formed at E9.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory