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Phenotypes Associated with This Genotype
Genotype
MGI:3605225
Allelic
Composition
Largevls/Largevls
Genetic
Background
B6.CAST(Cg)-Largevls/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Largevls mutation (0 available); any Large mutation (92 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• leakage from the vasculature in the perioptic disc region in 25% of mice as determined by fluorescein angiography (J:100214)
• retinal vessel tortuosity and increase in number of retinal vessels (J:100214)
• Background Sensitivity: in a segregating C57BL/6 and CAST background retinal vessel tortuosity is highly variable (J:100214)
• leakage from the vasculature in the perioptic disc region in 25% of mice as determined by fluorescein angiography (J:100214)
• retinal vessel tortuosity and increase in number of retinal vessels (J:100214)
• Background Sensitivity: in a segregating C57BL/6 and CAST background retinal vessel tortuosity is highly variable (J:100214)
• layer is disorganized with a reduction in synaptic complexes (J:100214)
• layer is thinner than in control littermates (J:100214)
• layer is disorganized with a reduction in synaptic complexes (J:100214)
• layer is thinner than in control littermates (J:100214)
• exhibits intracellular edema (J:100214)
• exhibits intracellular edema (J:100214)
• appears disorganized (J:100214)
• appears disorganized (J:100214)
• exhibits intracellular edema (J:100214)
• exhibits intracellular edema (J:100214)
• thinning of layer observed with aging (J:100214)
• thinning of layer observed with aging (J:100214)
• layer is disorganized with a reduction in synaptic complexes (J:100214)
• layer is disorganized with a reduction in synaptic complexes (J:100214)
• layer is thinner than in control littermates (J:100214)
• layer is thinner than in control littermates (J:100214)
• bilateral pigmented or non-pigmented vitreal masses (J:100214)
• bundles of axons and thick walled blood vessels observed in peripheral vitreous (J:100214)
• bilateral pigmented or non-pigmented vitreal masses (J:100214)
• bundles of axons and thick walled blood vessels observed in peripheral vitreous (J:100214)
• exhibits fibrous tissue in the vitreous body that appears cobweb or veil-like (J:100214)
• exhibits fibrous tissue in the vitreous body that appears cobweb or veil-like (J:100214)
• amplitude of b-wave responses is reduced and delayed at all flash intensities in 2 month old mice (J:100214)
• larger negative polarity a-wave in response to intermediate flash intensities in 2 month old mice (J:100214)
• maximum amplitude of a-wave reduced in response to highest flash intensities in 2 month old mice (J:100214)
• amplitude of b-wave responses is reduced and delayed at all flash intensities in 2 month old mice (J:100214)
• larger negative polarity a-wave in response to intermediate flash intensities in 2 month old mice (J:100214)
• maximum amplitude of a-wave reduced in response to highest flash intensities in 2 month old mice (J:100214)

muscle
• adult onset (J:100214)
• adult onset (J:100214)
• exhibits prominent interstial fibrosis with extensive degeneration and regeneration of myofibers at 1.5 months of age (J:100214)
• by 4 months diaphragm exhibits necrosis and fatty infiltration (J:100214)
• exhibits prominent interstial fibrosis with extensive degeneration and regeneration of myofibers at 1.5 months of age (J:100214)
• by 4 months diaphragm exhibits necrosis and fatty infiltration (J:100214)
• occasional signs of fiber-type grouping in 6 month old mice (J:100214)
• occasional signs of fiber-type grouping in 6 month old mice (J:100214)

growth/size/body

homeostasis/metabolism
• four-fold higher compared to control (J:100214)
• four-fold higher compared to control (J:100214)

behavior/neurological
• 50% reduction in grip strength (J:100214)
• 50% reduction in grip strength (J:100214)

cardiovascular system
• leakage from the vasculature in the perioptic disc region in 25% of mice as determined by fluorescein angiography (J:100214)
• retinal vessel tortuosity and increase in number of retinal vessels (J:100214)
• Background Sensitivity: in a segregating C57BL/6 and CAST background retinal vessel tortuosity is highly variable (J:100214)
• leakage from the vasculature in the perioptic disc region in 25% of mice as determined by fluorescein angiography (J:100214)
• retinal vessel tortuosity and increase in number of retinal vessels (J:100214)
• Background Sensitivity: in a segregating C57BL/6 and CAST background retinal vessel tortuosity is highly variable (J:100214)
• myocardium exhibits mild to moderate areas of cardiomyocyte degeneration with mycytolysis, necrosis and interstitial fibrosis in 5 month old mice (J:100214)
• lesions observed in the left and right atria and ventricles (J:100214)
• myocardium exhibits mild to moderate areas of cardiomyocyte degeneration with mycytolysis, necrosis and interstitial fibrosis in 5 month old mice (J:100214)
• lesions observed in the left and right atria and ventricles (J:100214)
• adult onset (J:100214)
• adult onset (J:100214)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory