Analysis Tools
hematopoietic system
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• increased splenic weight by 7 to 8 months of age in a high percentage of diseased mice
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• increased bone marow monocytic population with a decreased percentage of mature erythroid progenitors in some affected mice
• increased bone marrow granulocytes in some affected mice
• altered bone marrow granulocyt-macrophage progenitors such that more clusters than colonies are observed in appropriately cultured bone marrow from diseased mice
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• granulocytosis in many diseased mice
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• monocytosis in many diseased mice
• increased monocyte count in some affected mice
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• increased numbers of splenic granulocytes, monocytes, or erythroid cells in some affected animals
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• atypical nuclei in some splenocytes characteristic of dysplasia
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immune system
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• increased splenic weight by 7 to 8 months of age in a high percentage of diseased mice
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• granulocytosis in many diseased mice
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• monocytosis in many diseased mice
• increased monocyte count in some affected mice
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• increased numbers of splenic granulocytes, monocytes, or erythroid cells in some affected animals
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• atypical nuclei in some splenocytes characteristic of dysplasia
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growth/size/body
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• increased splenic weight by 7 to 8 months of age in a high percentage of diseased mice
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