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Phenotypes Associated with This Genotype
Genotype
MGI:3604219
Allelic
Composition
Fmr1tm1Cidz/Fmr1tm1Cidz
Tg(Pcp2-cre)2Mpin/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1tm1Cidz mutation (0 available); any Fmr1 mutation (22 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• the percentage, amplitude, and velocity of conditioned responses were reduced in the 3rd and 4th training sessions; however the startle response was normal

nervous system
• the length of Purkinje cell spine heads and necks is increased
• induction of long term depression in Purkinje cells is significantly enhanced when stimulating parallel fibers

Mouse Models of Human Disease
OMIM ID Ref(s)
Fragile X Mental Retardation Syndrome 300624 J:101021


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory