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Phenotypes Associated with This Genotype
Genotype
MGI:3603949
Allelic
Composition		 Apctm1Mmt/Apc+
Ptgs2tm1Jed/Ptgs2+
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Mmt mutation (0 available); any Apc mutation (154 available)
Ptgs2tm1Jed mutation (1 available); any Ptgs2 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine morphology ( J:36816 )
• at 10 weeks, double heterozygotes develop only ~34% of the polyp number detected in the intestinal tracts of mice heterozygous for Apctm1Mmt alone
colon polyps ( J:36816 )
• at 10 weeks, double heterozygotes exhibit only 1.5 1.9 colonic polyps versus 6.8 7.2 detected in mice heterozygous for Apctm1Mmt alone

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory