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Phenotypes Associated with This Genotype
Genotype
MGI:3603666
Allelic
Composition
Men1tm1.2Ctre/Men1tm1.2Ctre
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm1.2Ctre mutation (1 available); any Men1 mutation (40 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• abnormally large islets with pleomorphic cells of variable size and shape are seen at 4 weeks of age
• in 60 week old mutants islet volume has increased 20- to 26-fold
• foci of adenoma develop within the hyperplastic islets by 20 - 28 weeks of age and multiple adenomas are seen by 23 weeks of age
• 19 of 34 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes
• a sex bias is seen with 13 of 16 virgin females developing adenomas compared to 6 of 18 males

homeostasis/metabolism
• fasting blood glucose levels are decreased
• fasting serum insulin levels are increased

neoplasm
• foci of adenoma develop within the hyperplastic islets by 20 - 28 weeks of age and multiple adenomas are seen by 23 weeks of age
• 19 of 34 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes
• a sex bias is seen with 13 of 16 virgin females developing adenomas compared to 6 of 18 males


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory