endocrine/exocrine glands
• abnormally large islets with pleomorphic cells of variable size and shape are seen at 4 weeks of age
• in 60 week old mutants islet volume has increased 20- to 26-fold
|
• foci of adenoma develop within the hyperplastic islets by 20 - 28 weeks of age and multiple adenomas are seen by 23 weeks of age
• 19 of 34 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes
• a sex bias is seen with 13 of 16 virgin females developing adenomas compared to 6 of 18 males
|
homeostasis/metabolism
• fasting blood glucose levels are decreased
|
• fasting serum insulin levels are increased
|
neoplasm
• foci of adenoma develop within the hyperplastic islets by 20 - 28 weeks of age and multiple adenomas are seen by 23 weeks of age
• 19 of 34 homozygous floxed mutants had adenomas by the date of the scheduled autopsy and tumor incidence in homozygous mutants correlates to the level of Cre expression for the different cre transgenes
• a sex bias is seen with 13 of 16 virgin females developing adenomas compared to 6 of 18 males
|