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Phenotypes Associated with This Genotype
Genotype
MGI:3603147
Allelic
Composition
CrygbClapper/CrygbClapper
Genetic
Background
C57BL/6J-CrygbClapper
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CrygbClapper mutation (1 available); any Crygb mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cataracts in CrygbClapper/CrygbClapper and CrygbClapper/Crygb+ mice

vision/eye
• develop dominant lamellar cataracts with lens opacity decreasing as mice age
• cataract in 3 week old homozygotes occupies the inner region and covers about 75% of the lens
• darkly stained aggregates, enlarged interfiber spaces (about 3 times wider), and disorganized and smaller inner mature fibers are seen in region of cataract

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract 39 multiple types DOID:0110236 OMIM:615188
J:100851


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory