Mouse Genome Informatics
involves: C3H * C57BL/6
phenotype observed in females
phenotype observed in males
N normal phenotype

• by 8 months of age, begin to lose weight

• over time become unable to feed themselves
• by 8 months of age, grooming is neglected
• unable to right themselves when placed on their sides
• temulous motion is seen in some mice, possibly related to attempted muscular activity
• eventually are unable to stand up and support their own body weight
• develop hunched backs by 8 months of age
• by 8 months of age, exhibit severe movement impairment with resistance to passive movement and partial paralysis of limbs, accompanied by periods of freezing of hindlimb
• reduced ambulation by 8 months of age
• partial paralysis of limbs is observed by 8 months of age, beginning at a hindleg but affecting all limbs within a few days

nervous system
• astrocytic gliosis
• endoneurial space is increased and axons are filled with vacuoles in the ventral roots of aged mice
• develop age-dependent intracytoplasmic neuronal alpha-synuclein inclusions that contain 10-16 nm wide fibrils similar to those seen in human alpha-synucleinopathies, with dense accumulation in the spinal cord, brainstem, cerebellum, and thalamus
• show signs of neurodegeneration by 8 months of age and develop neurodegenerative disease within 16 months of age
• significant axonal degeneration in aged mice
• following axonal degeneration, the myelin sheath loosens and unravels

• exhibit sparse neurogenic muscle atrophy

Mouse Models of Human Disease
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:76657