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Phenotypes Associated with This Genotype
Genotype
MGI:3603015
Allelic
Composition
Myctm1Lbox/Myc+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myctm1Lbox mutation (0 available); any Myc mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Histopathological analysis of lymphomas in Myctm1Lbox/Myctm1Lbox and Myctm1Lbox/Myc+ mice

growth/size/body
• around 12 months of age profound enlargement of the spleen is seen
• around 12 months of age, a 5-12 fold increase in spleen weight seen

mortality/aging
• mean age of death is about 379 days

immune system
• around 12 months of age profound enlargement of the spleen is seen
• around 12 months of age, a 5-12 fold increase in spleen weight seen
• in young (6 weeks-3months) mutants, the percentage of B cells in the spleen is increased with a significant increase in the B220+IgM+IgDlow cell population and a slight increase in the B220+IgM+ cell population is seen in the bone marrow
• around 12 months of age profound enlargement of the lymph nodes is seen

neoplasm
• B cell derived lymphomas with diffuse infiltration in the spleen and lymph nodes, varying degrees of infiltration into the lung, kidney, and intestine, and a 'starry sky' appearance characteristic of Burkitt's lymphoma are seen

hematopoietic system
• around 12 months of age profound enlargement of the spleen is seen
• around 12 months of age, a 5-12 fold increase in spleen weight seen
• in young (6 weeks-3months) mutants, the percentage of B cells in the spleen is increased with a significant increase in the B220+IgM+IgDlow cell population and a slight increase in the B220+IgM+ cell population is seen in the bone marrow

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Burkitt lymphoma DOID:8584 OMIM:113970
J:97900


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory