Phenotypes Associated with This Genotype

Genotype
MGI:3590553

• Allelic Composition: Phc1^tm1Os/Phc1^tm1Os
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:100027 )

• mutants are alive at E17.5 but do not survive birth

craniofacial

abnormal occipital bone morphology ( J:100027 )

• an ectopic arch is associated with the occipital bones

abnormal sphenoid bone morphology ( J:100027 )

• the sphenoid is partially split

abnormal presphenoid bone morphology ( J:100027 )

• the center of the presphenoid is not ossified

cleft secondary palate ( J:100027 )

skeleton

abnormal occipital bone morphology ( J:100027 )

• an ectopic arch is associated with the occipital bones

abnormal sphenoid bone morphology ( J:100027 )

• the sphenoid is partially split

abnormal presphenoid bone morphology ( J:100027 )

• the center of the presphenoid is not ossified

abnormal vertebrae morphology ( J:100027 )

• changes in the vertebral column are similar to those in Phc2^tm1Hko

digestive/alimentary system

cleft secondary palate ( J:100027 )

growth/size/body

cleft secondary palate ( J:100027 )