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Phenotypes Associated with This Genotype
Genotype
MGI:3590228
Allelic
Composition
Tg(H2-Ea-Ins2)1Wehi/0
Genetic
Background
NOD/ShiLtJWehi-Tg(H2-Ea-Ins2)1Wehi
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Mouse lines carrying:
Tg(H2-Ea-Ins2)1Wehi mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• unlike wild-type NOD mice, transgenic NOD/LtWehi mice do not develop spontaneous diabetes (J:100232)
• whereas wildtype NOD mice are susceptible to diabetes induction by cyclophosphamide, no transgenic NOD/LtWehi mice became diabetic (defined as blood glucose > 11 mmol/l) after a single cyclophosphamide injection; following a second injection only one of ten developed diabetes, and it was more slowly progressive than in wild-type controls (J:100232)
• pancreata of transgenic NOD/LtWehi mice are almost entirely free of insulitis: 90% of 244 islets from 100-day-old female mice and 98% of 259 islets from 147-day-old males had no cellular infiltration, and the rest exhibited only a minimal degree of insulitis (J:100232)
• unlike wild-type NOD mice, transgenic NOD/LtWehi mice do not develop spontaneous diabetes (J:100232)
• whereas wildtype NOD mice are susceptible to diabetes induction by cyclophosphamide, no transgenic NOD/LtWehi mice became diabetic (defined as blood glucose > 11 mmol/l) after a single cyclophosphamide injection; following a second injection only one of ten developed diabetes, and it was more slowly progressive than in wild-type controls (J:100232)
• pancreata of transgenic NOD/LtWehi mice are almost entirely free of insulitis: 90% of 244 islets from 100-day-old female mice and 98% of 259 islets from 147-day-old males had no cellular infiltration, and the rest exhibited only a minimal degree of insulitis (J:100232)
• the transgene does not affect the characteristic susceptibility of NOD mice to sialitis, the degree of which does not differ significantly between transgenic NOD/LtWis mice and control littermates (J:100232)
• the transgene does not affect the characteristic susceptibility of NOD mice to sialitis, the degree of which does not differ significantly between transgenic NOD/LtWis mice and control littermates (J:100232)

immune system
N
• pancreata of transgenic NOD/LtWehi mice are almost entirely free of insulitis: 90% of islets from 100-day-old female mice and 98% of those from 147-day-old males have no cellular infiltration, and the rest exhibit only a minimal degree of insulitis (J:100232)
• pancreata of transgenic NOD/LtWehi mice are almost entirely free of insulitis: 90% of islets from 100-day-old female mice and 98% of those from 147-day-old males have no cellular infiltration, and the rest exhibit only a minimal degree of insulitis (J:100232)
• the transgene does not affect the characteristic susceptibility of NOD mice to sialitis, the degree of which does not differ significantly between transgenic NOD/LtWis mice and control littermates (J:100232)
• the transgene does not affect the characteristic susceptibility of NOD mice to sialitis, the degree of which does not differ significantly between transgenic NOD/LtWis mice and control littermates (J:100232)
• spleen- and draining lymph node-derived T cells from wild-type and transgenic NOD/LtWehi mice exhibit statistically similar in vitro proliferative responses to peptides derived from proinsulin and GAD2 (GAD65) following immunization with these self antigens (J:100232)
• spleen- and draining lymph node-derived T cells from wild-type and transgenic NOD/LtWehi mice exhibit statistically similar in vitro proliferative responses to peptides derived from proinsulin and GAD2 (GAD65) following immunization with these self antigens (J:100232)

digestive/alimentary system
• the transgene does not affect the characteristic susceptibility of NOD mice to sialitis, the degree of which does not differ significantly between transgenic NOD/LtWis mice and control littermates (J:100232)
• the transgene does not affect the characteristic susceptibility of NOD mice to sialitis, the degree of which does not differ significantly between transgenic NOD/LtWis mice and control littermates (J:100232)

hematopoietic system
• spleen- and draining lymph node-derived T cells from wild-type and transgenic NOD/LtWehi mice exhibit statistically similar in vitro proliferative responses to peptides derived from proinsulin and GAD2 (GAD65) following immunization with these self antigens (J:100232)
• spleen- and draining lymph node-derived T cells from wild-type and transgenic NOD/LtWehi mice exhibit statistically similar in vitro proliferative responses to peptides derived from proinsulin and GAD2 (GAD65) following immunization with these self antigens (J:100232)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:100251


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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory