Phenotypes Associated with This Genotype

Genotype
MGI:3590155

• Allelic Composition: Il15^tm1Imx/Il15^tm1Imx
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:84009 )

• improved survival after infection with Listeria monocytogenes

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:97038 )

• very susceptible to HSV-2 infection

increased susceptibility to Poxviridae infection induced morbidity/mortality ( J:60915 )

• dead by day 9 after Vaccinia infection

immune system

abnormal immune system morphology ( J:60915 )

decreased dendritic cell number ( J:97620 )

• lower numbers of splenic dendritc cells after Plasmodium chabaudi infection

abnormal lymphocyte morphology ( J:60915 )

• Intestinal intraepithelial lymphocytes maturing outside of the thymus are greatly reduced in numbers

decreased NK cell number ( J:60915 , J:132730 , J:142654 )

• reduced numbers of natural killer cells in thymus, liver and spleen (J:60915)

• NK cell numbers in the intestine are reduced by 100-fold (J:142654)

• however, the Ncr(NKp46)⁺CD127⁺ NK1.1^- subset of intestinal natural killer cells is unaffected (J:142654)

absent uterine NK cells ( J:84009 )

♀ • absent in uterus

decreased CD8-positive, alpha-beta T cell number ( J:60915 , J:113408 )

• two fold reduction in numbers of CD8 single positive cells in spleen and lymph nodes (J:60915)

• there is a 2-fold loss in total CD8⁺ T cell numbers and a 3-fold reduction in numbers of CD8⁺CD44^hi T cells (J:113408)

decreased CD8-positive, gamma-delta intraepithelial T cell number ( J:155298 )

• marked reduction

decreased memory T cell number ( J:132730 )

decreased regulatory T cell number ( J:208318 )

• by 12 months

small lymph nodes ( J:60915 )

• periferal lymph nodes significantly lower in weight

• decreased cellularity

abnormal immune system physiology ( J:60915 )

decreased immunoglobulin level ( J:97620 )

• lower levels of malaria specific antibodies produced

• lower levels of total immune globulin

decreased IgG level ( J:97620 )

• decreased levels of IgG1, IgG2a, IgG2b, and IgG3 after Plasmodium infection

decreased IgM level ( J:97620 )

• after plasmodium infection

impaired natural killer cell mediated cytotoxicity ( J:97620 )

• significantly reduced cytolytic activity

abnormal CD8-positive, alpha-beta T cell physiology ( J:95221 )

• CD8⁺ T cell proliferation in vitro is not enhanced in the presence of IL-21 in the same manner as wild-type CD8⁺ T cells

decreased susceptibility to type IV hypersensitivity reaction ( J:87137 )

• no contact hypersensitivity

• T mediated effects delayed but not B cell activation or antibody production

abnormal cytokine secretion ( J:97620 )

decreased interferon-gamma secretion ( J:97620 )

• reduced production of IFN gamma by NK cells

decreased interleukin-12 secretion ( J:97620 )

• reduced Il12 production by dendritic cells after Plasmodium infection

abnormal susceptibility to infection ( J:60915 )

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:84009 )

• improved survival after infection with Listeria monocytogenes

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:97038 )

• very susceptible to HSV-2 infection

increased susceptibility to Poxviridae infection induced morbidity/mortality ( J:60915 )

• dead by day 9 after Vaccinia infection

increased susceptibility to parasitic infection ( J:97620 )

• parasitemia higher but only minor effect on mortality

reproductive system

absent uterine NK cells ( J:84009 )

♀ • absent in uterus

abnormal decidualization ( J:84009 )

♀ • marked acellularity of decidua relative to controls

♀ • thickened decidual arteries at days 12 and 14 of pregnancy

cardiovascular system

abnormal uterine artery morphology ( J:84009 )

♀ • thickened decidual arteries at days 12 and 14 of pregnancy

♀ • decidual artery walls thickened and lumen narrowed

♀ • first evidence of abnormality at day 10 of pregnancy and worsening with time

growth/size/body

decreased body weight ( J:84009 )

• slight but significant reduction in weight at birth

hematopoietic system

decreased dendritic cell number ( J:97620 )

• lower numbers of splenic dendritc cells after Plasmodium chabaudi infection

abnormal lymphocyte morphology ( J:60915 )

• Intestinal intraepithelial lymphocytes maturing outside of the thymus are greatly reduced in numbers

decreased NK cell number ( J:60915 , J:132730 , J:142654 )

• reduced numbers of natural killer cells in thymus, liver and spleen (J:60915)

• NK cell numbers in the intestine are reduced by 100-fold (J:142654)

• however, the Ncr(NKp46)⁺CD127⁺ NK1.1^- subset of intestinal natural killer cells is unaffected (J:142654)

absent uterine NK cells ( J:84009 )

♀ • absent in uterus

decreased CD8-positive, alpha-beta T cell number ( J:60915 , J:113408 )

• two fold reduction in numbers of CD8 single positive cells in spleen and lymph nodes (J:60915)

• there is a 2-fold loss in total CD8⁺ T cell numbers and a 3-fold reduction in numbers of CD8⁺CD44^hi T cells (J:113408)

decreased CD8-positive, gamma-delta intraepithelial T cell number ( J:155298 )

• marked reduction

decreased memory T cell number ( J:132730 )

decreased regulatory T cell number ( J:208318 )

• by 12 months

decreased immunoglobulin level ( J:97620 )

• lower levels of malaria specific antibodies produced

• lower levels of total immune globulin

decreased IgG level ( J:97620 )

• decreased levels of IgG1, IgG2a, IgG2b, and IgG3 after Plasmodium infection

decreased IgM level ( J:97620 )

• after plasmodium infection

impaired natural killer cell mediated cytotoxicity ( J:97620 )

• significantly reduced cytolytic activity

abnormal CD8-positive, alpha-beta T cell physiology ( J:95221 )

• CD8⁺ T cell proliferation in vitro is not enhanced in the presence of IL-21 in the same manner as wild-type CD8⁺ T cells

embryo

absent uterine NK cells ( J:84009 )

♀ • absent in uterus

abnormal decidualization ( J:84009 )

♀ • marked acellularity of decidua relative to controls

♀ • thickened decidual arteries at days 12 and 14 of pregnancy

endocrine/exocrine glands

absent uterine NK cells ( J:84009 )

♀ • absent in uterus