Phenotypes Associated with This Genotype

Genotype
MGI:3590136

• Allelic Composition: Atg7^tm1.1Tchi/Atg7^tm1.1Tchi
• Genetic Background: involves: C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:100199 )

• die within one day after birth

• die earlier compared with controls under starvation conditions after caesarean delivery (13 hours vs. 21 hours in controls)

growth/size/body

decreased body weight ( J:100199 )

• seen at birth

cellular

abnormal intracellular organelle morphology ( J:100199 )

• autophagosomes are absent

homeostasis/metabolism

abnormal circulating amino acid level ( J:100199 )

• lower concentrations of essential and branched-chain amino acids in the sera at 10 hours after caesarean delivery