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Phenotypes Associated with This Genotype
Genotype
MGI:3589738
Allelic
Composition		 Sit1tm1Lsmn/Sit1tm1Lsmn
Tg(TcrLCMV)327Sdz/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sit1tm1Lsmn mutation (0 available); any Sit1 mutation (14 available)
Tg(TcrLCMV)327Sdz mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:100408 )
• dramatic reduction of thymic cellularity
abnormal T cell selection ( J:100408 )
• altered thymic selection process
abnormal positive T cell selection ( J:100408 )
• enhanced positive selection of T cells and partial conversion of positive selection to negative selection

hematopoietic system
thymus hypoplasia ( J:100408 )
• dramatic reduction of thymic cellularity
abnormal T cell selection ( J:100408 )
• altered thymic selection process
abnormal positive T cell selection ( J:100408 )
• enhanced positive selection of T cells and partial conversion of positive selection to negative selection

endocrine/exocrine glands
thymus hypoplasia ( J:100408 )
• dramatic reduction of thymic cellularity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory