Phenotypes Associated with This Genotype

Genotype
MGI:3589737

• Allelic Composition: Sit1^tm1Lsmn/Sit1^tm1Lsmn; Tg(TcraH-Y,TcrbH-Y)71Vbo/?
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:100408 )

• more efficient suppression of the rearrangement of the endogenous TCR-alpha chain

abnormal positive T cell selection ( J:100408 )

• enhanced positive selection of T cells and partial conversion of positive selection to negative selection

abnormal CD8-positive, alpha beta T cell morphology ( J:100408 )

• CD8 single positive cells are more mature

hematopoietic system

abnormal T cell differentiation ( J:100408 )

• more efficient suppression of the rearrangement of the endogenous TCR-alpha chain

abnormal positive T cell selection ( J:100408 )

• enhanced positive selection of T cells and partial conversion of positive selection to negative selection

abnormal CD8-positive, alpha beta T cell morphology ( J:100408 )

• CD8 single positive cells are more mature