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Phenotypes Associated with This Genotype
Genotype
MGI:3589477
Allelic
Composition
Zfpm2lil/Zfpm2lil
Genetic
Background
involves: A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfpm2lil mutation (0 available); any Zfpm2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal pulmonary and diaphragmatic development in the Zfpm2lil/Zfpm2lil mouse

mortality/aging
• progressive loss of embryos is seen from E13.5 to E15.5; number surviving to birth is less than 5% of expected value (J:100119)
• 1 viable embryo was found on E18.5, while some mice were found dead after birth (J:100119)
• 1 viable embryo was found on E18.5, while some mice were found dead after birth (J:100119)
• progressive loss of embryos is seen from E13.5 to E15.5; number surviving to birth is less than 5% of expected value (J:100119)

respiratory system
• underdevelopment of the anterior portion of the right lung middle lobe (J:100119)
• underdevelopment of the anterior portion of the right lung middle lobe (J:100119)
• bilateral pulmonary hypoplasia including absence of an accessory lobe on the right side and underdevelopment of the anterior right middle lobe is seen (J:100119)
• bilateral pulmonary hypoplasia including absence of an accessory lobe on the right side and underdevelopment of the anterior right middle lobe is seen (J:100119)

cardiovascular system
• at E15.5 the endocardial cushions are enlarged and abnormally developed (J:100119)
• at E15.5 the endocardial cushions are enlarged and abnormally developed (J:100119)
• decreased vascularization of the myocardium is found at E15.5 (J:100119)
• decreased vascularization of the myocardium is found at E15.5 (J:100119)
• seen at E15.5 (J:100119)
• seen at E15.5 (J:100119)
• ostium primum atrial septal defects are seen in homozygotes that survive to birth (J:100119)
• ostium primum atrial septal defects are seen in homozygotes that survive to birth (J:100119)
• enlarged atria are seen in homozygotes that survive to birth (J:100119)
• enlarged atria are seen in homozygotes that survive to birth (J:100119)
• thinning of the outer compact layer at E15.5 (J:100119)
• thinning of the outer compact layer at E15.5 (J:100119)
• at E15.5, the myocardium is poorly developed with thinning of the outer compact layer (J:100119)
• at E15.5, the myocardium is poorly developed with thinning of the outer compact layer (J:100119)
• at E15.5 some embryos still have a complete atrioventricular canal (J:100119)
• at E15.5 some embryos still have a complete atrioventricular canal (J:100119)
• atrioventricular canal type ventricular septal defects are seen in homozygotes that survive to birth (J:100119)
• atrioventricular canal type ventricular septal defects are seen in homozygotes that survive to birth (J:100119)

muscle
• the diaphragm is intact but muscularization is absent in the dorsal regions with the few myotubes that are present radiating in a dorsal-ventral orientation and muscletissue does not meet the entire surface of the body walls (J:100119)
• the diaphragm is intact but muscularization is absent in the dorsal regions with the few myotubes that are present radiating in a dorsal-ventral orientation and muscletissue does not meet the entire surface of the body walls (J:100119)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diaphragmatic Hernia, Congenital 142340 J:100119


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory