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Phenotypes Associated with This Genotype
Genotype
MGI:3589472
Allelic
Composition
Col8a1tm1Bjro/Col8a1tm1Bjro
Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic
Background
B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col8a1tm1Bjro mutation (0 available); any Col8a1 mutation (7 available)
Col8a2tm1Bjro mutation (0 available); any Col8a2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• dysgenesis of the anterior segment of the eye
• Descemet's membrane is markedly thinner and banded structures within the Descemet's membrane are completely absent
• 21.5% reduction in stroma thickness
• corneal endothelial cells are enlarged and decreased in number and show a decreased ability to proliferate in response to different growth factors in vitro
• increased depth of the anterior chamber (392 um vs. 223 um in controls)
• globoid, keratoglobus-like protrusion of the anterior chamber


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory