About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3589409
Allelic
Composition
Alms1Gt(XH152)Byg/Alms1Gt(XH152)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alms1Gt(XH152)Byg mutation (0 available); any Alms1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight begins to increase between 8 - 12 weeks of age (J:100403)
• body weight begins to increase between 8 - 12 weeks of age (J:100403)
• adiposity indices are increased 3-fold and 2-fold in females and males, respectively, compared to littermate controls (J:100403)
• adiposity indices are increased 3-fold and 2-fold in females and males, respectively, compared to littermate controls (J:100403)

adipose tissue
• the amount of white fat is increased particularly in the subcutaneous and reproductive regions (J:100403)
• the amount of white fat is increased particularly in the subcutaneous and reproductive regions (J:100403)

homeostasis/metabolism
• plasma glucose levels are increased to over 250 mg/dl in males after 16 weeks of age; however in younger males and in females plasma glucose levels are only slightly elevated (J:100403)
• plasma glucose levels are increased to over 250 mg/dl in males after 16 weeks of age; however in younger males and in females plasma glucose levels are only slightly elevated (J:100403)
• hyperinsulnemia develops in males and females between 8 and 12 weeks of age (J:100403)
• hyperinsulnemia develops in males and females between 8 and 12 weeks of age (J:100403)
• at 20 weeks of age moderately increased plasma total cholesterol levels are seen; however plasma triglyceride levels are similar to controls (J:100403)
• at 20 weeks of age moderately increased plasma total cholesterol levels are seen; however plasma triglyceride levels are similar to controls (J:100403)
• micro- and macro-albuminuria is seen in males but not females at 24 weeks of age (J:100403)
• micro- and macro-albuminuria is seen in males but not females at 24 weeks of age (J:100403)
• calcium oxalate diphosphate crystals are frequently observed in urine sediments (J:100403)
• calcium oxalate diphosphate crystals are frequently observed in urine sediments (J:100403)

hearing/vestibular/ear
• in mice 8 months of age or older auditory brainstem response thresholds are increased to greater than 55 db sound pressure level; however morphology of the structures of the inner and middle ear appear normal (J:100403)
• in mice 8 months of age or older auditory brainstem response thresholds are increased to greater than 55 db sound pressure level; however morphology of the structures of the inner and middle ear appear normal (J:100403)

vision/eye
• at 24 weeks of age loss of cell bodies in the outer nuclear layer reduces it from 10 to 6 layers and the inner and outer segments are shortened (J:100403)
• at 24 weeks of age, mislocalization of rhodopsin to the outer nuclear layer is seen (J:100403)
• at 24 weeks of age loss of cell bodies in the outer nuclear layer reduces it from 10 to 6 layers and the inner and outer segments are shortened (J:100403)
• at 24 weeks of age, mislocalization of rhodopsin to the outer nuclear layer is seen (J:100403)
• at 9 weeks of age reduced cone b-wave responses are observed and by 24 weeks of age 33% of mutants show significantly reduced b-wave amplitudes (J:100403)
• at 9 weeks of age reduced cone b-wave responses are observed and by 24 weeks of age 33% of mutants show significantly reduced b-wave amplitudes (J:100403)

reproductive system
• variable atrophy of the seminiferous tubules from severe vacuolization with no secondary spermatocytes to testes that only lacked mature sperm is seen (J:100403)
• variable atrophy of the seminiferous tubules from severe vacuolization with no secondary spermatocytes to testes that only lacked mature sperm is seen (J:100403)
• hypogonadism is seen in all homozygotes (J:100403)
• hypogonadism is seen in all homozygotes (J:100403)

renal/urinary system
• micro- and macro-albuminuria is seen in males but not females at 24 weeks of age (J:100403)
• micro- and macro-albuminuria is seen in males but not females at 24 weeks of age (J:100403)
• calcium oxalate diphosphate crystals are frequently observed in urine sediments (J:100403)
• calcium oxalate diphosphate crystals are frequently observed in urine sediments (J:100403)
• at 24 weeks of age, interstitial inflammation and vacuolization is seen suggesting degeneration of the tubules (J:100403)
• at 24 weeks of age, interstitial inflammation and vacuolization is seen suggesting degeneration of the tubules (J:100403)
• at 6 months of age, kidneys are enlarged (J:100403)
• at 6 months of age, kidneys are enlarged (J:100403)
• at 6 months of age, kidneys are about twice the weight of normal kidneys (J:100403)
• at 6 months of age, kidneys are about twice the weight of normal kidneys (J:100403)
• at 6 months of age, the proximal tubules are dilated and contain eosin-positive, flocculent material (J:100403)
• at 6 months of age, the proximal tubules are dilated and contain eosin-positive, flocculent material (J:100403)

liver/biliary system
• macro- and micro-vesicular lipid deposits are seen in 24 - 30 week old mice (J:100403)
• macro- and micro-vesicular lipid deposits are seen in 24 - 30 week old mice (J:100403)

cellular
N
• cilia assembly and morphology of cilia in the nasal epithelium, renal tubules, and retina are normal (J:100403)
• cilia assembly and morphology of cilia in the nasal epithelium, renal tubules, and retina are normal (J:100403)

immune system
• at 24 weeks of age, interstitial inflammation and vacuolization is seen suggesting degeneration of the tubules (J:100403)
• at 24 weeks of age, interstitial inflammation and vacuolization is seen suggesting degeneration of the tubules (J:100403)

endocrine/exocrine glands
• partial degranulation of islet beta cells is seen compared to wild-type mice (J:100403)
• partial degranulation of islet beta cells is seen compared to wild-type mice (J:100403)
• islets are severely enlarged and hyperplastic (J:100403)
• islets are severely enlarged and hyperplastic (J:100403)
• variable atrophy of the seminiferous tubules from severe vacuolization with no secondary spermatocytes to testes that only lacked mature sperm is seen (J:100403)
• variable atrophy of the seminiferous tubules from severe vacuolization with no secondary spermatocytes to testes that only lacked mature sperm is seen (J:100403)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alstrom Syndrome; ALMS 203800 J:100403
Obesity 601665 J:100403


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory