Phenotypes Associated with This Genotype

Genotype
MGI:3588767

• Allelic Composition: F5^tm2Dgi/F5^tm2Dgi
• Genetic Background: B6.129S2-F5^tm2Dgi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:66260 )

• Background Sensitivity: do not observe postnatal lethality on the predominately C57BL/6J background like on the mixed 129 and C57BL/6J background, however crossing back to 129/SvJ or 129SvIm/J mice, results in about 50% postnatal loss

homeostasis/metabolism

abnormal blood coagulation ( J:66260 )

• chronic, low-grade thrombin generation leading to enhanced fibrin deposition in multiple tissues, however do not observe thrombosis

liver/biliary system

liver fibrosis ( J:66260 )

• occasional focal hepatic fibrosis is seen