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Phenotypes Associated with This Genotype
Genotype
MGI:3588183
Allelic
Composition
Trp63tm1Brd/Trp63tm1Brd
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Brd mutation (0 available); any Trp63 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death occurs within several hours of birth

embryo
• small and misshapen at E11.5

limbs/digits/tail
• small and misshapen at E11.5
• all are missing
• usually truncated, thinner than normal and deformed
• sometimes absent

skeleton
• all are missing
• usually truncated, thinner than normal and deformed
• sometimes absent
• pelvic girdle usually present but lacking ossification centers

craniofacial
• "abnormal facies"

homeostasis/metabolism
• water loss occurs 30X more rapidly than in controls, a skin permeability problem

integument
• skin at birth totally lacks hair follicles
• reduced to a single layer of flattened cells
• epithelium of tongue and oral cavity is similar to the epidermis
• epidermal development apparently stops around E9.5
• water loss occurs 30X more rapidly than in controls, a skin permeability problem

growth/size/body
• "abnormal facies"


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory