Mouse Genome Informatics
hm
    Ndst1tm1Hgx/Ndst1tm1Hgx
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• pups died within 10 hours of birth

respiratory system
• immature type II pneumocytes with glycogen accumulations, reduced numbers of lamellar bodies and attenuated microvilli
• reduced numbers of lamellar bodies in type II cells
• gasping breath
• less secreted surfactant protein but produced by more cells
• lungs fail to inflate at birth although branching morphology normal

homeostasis/metabolism

Mouse Models of Human Disease
OMIM IDRef(s)
Respiratory Distress Syndrome in Premature Infants 267450 J:60280