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Phenotypes Associated with This Genotype
Genotype
MGI:3587788
Allelic
Composition
Ndst1tm1Hgx/Ndst1tm1Hgx
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1tm1Hgx mutation (0 available); any Ndst1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups died within 10 hours of birth

respiratory system
• immature type II pneumocytes with glycogen accumulations, reduced numbers of lamellar bodies and attenuated microvilli
• reduced numbers of lamellar bodies in type II cells
• gasping breath
• less secreted surfactant protein but produced by more cells
• lungs fail to inflate at birth although branching morphology normal

homeostasis/metabolism

Mouse Models of Human Disease
OMIM ID Ref(s)
Respiratory Distress Syndrome in Premature Infants 267450 J:60280


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory