Mouse Genome Informatics
hm
    Ndst1tm1Ekf/Ndst1tm1Ekf
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Newborn Ndst1tm1Ekf/Ndst1tm1Ekf mice display lung atelectasia

mortality/aging
• pups cyanotic and died neonatally
• some death between E14.5 and E18.5

respiratory system
• less secreted surfactant protein but produced by more cells
• lungs fail to inflate at birth

homeostasis/metabolism

Mouse Models of Human Disease
OMIM IDRef(s)
Respiratory Distress Syndrome in Premature Infants 267450 J:63996