Phenotypes Associated with This Genotype

Genotype
MGI:3587786

• Allelic Composition: Ndst1^tm1Ekf/Ndst1^tm1Ekf
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Newborn Ndst1^tm1Ekf/Ndst1^tm1Ekf mice display lung atelectasia

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:63996 )

• some death between E14.5 and E18.5

neonatal lethality, complete penetrance ( J:63996 )

• pups cyanotic and died neonatally

respiratory system

atelectasis ( J:63996 )

• lungs fail to inflate at birth

respiratory failure ( J:63996 )

abnormal surfactant secretion ( J:63996 )

• less secreted surfactant protein but produced by more cells

homeostasis/metabolism

cyanosis ( J:63996 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
newborn respiratory distress syndrome		DOID:12716	OMIM:267450	J:63996