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Phenotypes Associated with This Genotype
Genotype
MGI:3587766
Allelic
Composition
Tsc1tm1Chdl/Tsc1+
Genetic
Background
involves: 129P2/OlaHsd * Balb/cOlaHsd * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsc1tm1Chdl mutation (0 available); any Tsc1 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• hemangioma consisted of abnormal vascular channels and smooth muscle are found 18% of 15-18 month mice

renal/urinary system
• renal lesion classified as cysts, atypical cysts, branching cysts, mixed cystic/solid carcinomas or solid carcinomas developed 15-18 month
• onset and frequency are less severe compared to background involving C3H
• 80% of mice with solid renal cell carcinoma (RCC) by 15-18 month
• many RCC were larger than 5 mm which resulted in grossly deformed kidney
• renal lesion classified as cysts, atypical cysts, branching cysts, mixed cystic/solid carcinomas or solid carcinomas developed 15-18 month
• onset and frequency are less severe compared to background involving C3H

neoplasm
• hemangioma consisted of abnormal vascular channels and smooth muscle are found 18% of 15-18 month mice
• renal lesion classified as cysts, atypical cysts, branching cysts, mixed cystic/solid carcinomas or solid carcinomas developed 15-18 month
• onset and frequency are less severe compared to background involving C3H
• 80% of mice with solid renal cell carcinoma (RCC) by 15-18 month
• many RCC were larger than 5 mm which resulted in grossly deformed kidney

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
tuberous sclerosis DOID:13515 OMIM:191100
OMIM:613254
J:99796


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory