Mouse Genome Informatics
involves: DBA/2 * T STOCK
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• in the first postnatal week, degeneration of the lens nucleus and cortical fibers continues (J:16467)
• by the second postnatal week, lenses appear amorphous except at the epithelium and at the equitorial cortex (J:16467)
• at E15, lens material extrudes through minute defects in the capsule; also observed at subsequent ages (J:16467)
• by P21, rupture of the lens capsule is seen in all mice (J:16467)
• at E14, small vacuoles appear in the center of the developing lens (J:16467)
• by E17 and E18, these vacuoles expand to form large cavities (J:16467)
• at E14, an irregular arrangement of round primary fibers is seen, in contrast to the enlongated fibers of control lenses (J:16467)
• at E15, the primary fibers in the center of the lens contain larger vacuoles and show evidence of dissolution, but peripheral fibers appear normal (J:16467)
• at E17-E18, vacuoles are seen in secondary lens fibers, indicating degeneration (J:16467)
• by the first postnatal week, cytological architecture is no longer recognizable in the primary fibers (J:16467)
• total lens opacity (J:14118)

Mouse Models of Human Disease
Nance-Horan Syndrome; NHS 302350 J:19674 , J:89306