Mouse Genome Informatics
hm
    Chrna4tm1Dra/Chrna4tm1Dra
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• mutant mice do not display DAC (which consists of three distinct stereotypic behaviors - saccadic behavior, forelimb dystonia, Straub tail) after injection with 2, 6, or 8 mg/kg nicotine (J:125305)
• under an unhabituated or habituated condition, nicotine administration produced a smaller and delayed decline in sniffing, locomotion, total rearing, and sifting than in wild-type
• under normal conditions, homozygous null mice do not develop spontaneous seizures, however following administration of the GABA antagonist, pentylenetetrazole (PTZ), homozygous null mice show increased mortality, greater number of generalized clonic seizures, and EEGs with increased spikes, multi-spike complexes and continuous fast activity
• spend less time in open arms and make fewer open-arm entries in an elevated plus-maze, indicating increased anxiety
• over an initial 1 hour phase of exploratory behavior in a novel environment, exhibit increased sniffing and decreased grooming
• over a subsequent phase of habituation, mice also exhibit increased sniffing, increased locomotion, and a reduced rate of habituation
• exhibit decreased grooming over an initial 1 hour phase of exploratory behavior in a novel environment
• over a subsequent phase of habituation in a new environment, exhibit increased locomotion
• over a subsequent phase of habituation, exhibit an increase in total rearing, rearing seated, rearing to wall, and rearing free

nervous system
• under normal conditions, homozygous null mice do not develop spontaneous seizures, however following administration of the GABA antagonist, pentylenetetrazole (PTZ), homozygous null mice show increased mortality, greater number of generalized clonic seizures, and EEGs with increased spikes, multi-spike complexes and continuous fast activity
• EEGs with increased spikes, multi-spike complexes and continuous fast activity are observed when mice receive a GABA antagonist

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Epilepsy, Nocturnal Frontal Lobe, 1; ENFL1 600513 J:64208 , J:97020