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Phenotypes Associated with This Genotype
Genotype
MGI:3587032
Allelic
Composition
Hoxa13Hd/Hoxa13Hd
Genetic
Background
B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13Hd mutation (1 available); any Hoxa13 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• 5 of 6 females exhibit a reduced ano-vaginal distance (J:58731)
• 5 of 6 females exhibit a reduced ano-vaginal distance (J:58731)
• 2 of 3 males exhibit bowel obstructions (J:58731)
• 2 of 3 males exhibit bowel obstructions (J:58731)

renal/urinary system
• one third of females exhibit urinary tract defects (J:58731)
• one third of females exhibit urinary tract defects (J:58731)
• 1 of 18 females exhibt a hypoplastic kidney (J:58731)
• 1 of 18 females exhibt a hypoplastic kidney (J:58731)
• 3 of 18 females exhibit cystic kidneys (J:58731)
• 3 of 18 females exhibit cystic kidneys (J:58731)
• the proximal part of the penial bone is mishapen (J:58731)
• the proximal part of the penial bone is mishapen (J:58731)
• the proximal part of the penial bone is smaller (J:58731)
• the proximal part of the penial bone is smaller (J:58731)
• urethra is abnormally located within the serosal layer in females (J:58731)
• urethra is abnormally located within the serosal layer in females (J:58731)
• 1 of 18 females lack a bladder (J:58731)
• 1 of 18 females lack a bladder (J:58731)
• 2 of 3 males exhibit cystic bladders (J:58731)
• 2 of 3 males exhibit cystic bladders (J:58731)
• 1 of 3 males exhibit a hypoplastic bladder (J:58731)
• 1 of 3 males exhibit a hypoplastic bladder (J:58731)
• 1 of 18 females exhibit an abnormal fistula connecting the bladder and vaginal cavity (J:58731)
• 1 of 18 females exhibit an abnormal fistula connecting the bladder and vaginal cavity (J:58731)

reproductive system
• 5 of 6 females exhibit a reduced ano-vaginal distance (J:58731)
• 5 of 6 females exhibit a reduced ano-vaginal distance (J:58731)
• the proximal part of the penial bone is mishapen (J:58731)
• the proximal part of the penial bone is mishapen (J:58731)
• the proximal part of the penial bone is smaller (J:58731)
• the proximal part of the penial bone is smaller (J:58731)
• 1 of 18 females exhibit an abnormal fistula connecting the bladder and vaginal cavity (J:58731)
• 1 of 18 females exhibit an abnormal fistula connecting the bladder and vaginal cavity (J:58731)
• stromal tissue surrounding the cervical canals is smaller and the cervical canal is greatly reduced in size (J:58731)
• the columnar-to-squamosal epithelial transition that characterizes mature cervical-vaginal tissue is positioned within uterine-like stroma rather than cervical tissue (J:58731)
• exhibit an anterior transformation of cervical tissue to a uterine stromal phenotype (J:58731)
• stromal tissue surrounding the cervical canals is smaller and the cervical canal is greatly reduced in size (J:58731)
• the columnar-to-squamosal epithelial transition that characterizes mature cervical-vaginal tissue is positioned within uterine-like stroma rather than cervical tissue (J:58731)
• exhibit an anterior transformation of cervical tissue to a uterine stromal phenotype (J:58731)
• cervix is hypoplastic (J:58731)
• cervix is hypoplastic (J:58731)
• 5 of 18 females exhibit enlarged, fluid-filled uterine horns (J:58731)
• 5 of 18 females exhibit enlarged, fluid-filled uterine horns (J:58731)
• profoundly small vaginal cavity (J:58731)
• profoundly small vaginal cavity (J:58731)
(J:58731)
(J:58731)
(J:58731)
(J:58731)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hand-Foot-Genital Syndrome; HFG 140000 J:58731


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory