Mouse Genome Informatics
hm
    Hoxa13Hd/Hoxa13Hd
B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
digestive/alimentary system
• 5 of 6 females exhibit a reduced ano-vaginal distance (J:58731)
• 2 of 3 males exhibit bowel obstructions (J:58731)

renal/urinary system
• one third of females exhibit urinary tract defects (J:58731)
• 1 of 18 females exhibt a hypoplastic kidney (J:58731)
• 3 of 18 females exhibit cystic kidneys (J:58731)
• the proximal part of the penial bone is mishapen (J:58731)
• the proximal part of the penial bone is smaller (J:58731)
• urethra is abnormally located within the serosal layer in females (J:58731)
• 1 of 18 females lack a bladder (J:58731)
• 2 of 3 males exhibit cystic bladders (J:58731)
• 1 of 3 males exhibit a hypoplastic bladder (J:58731)
• 1 of 18 females exhibit an abnormal fistula connecting the bladder and vaginal cavity (J:58731)

reproductive system
• 5 of 6 females exhibit a reduced ano-vaginal distance (J:58731)
• the proximal part of the penial bone is mishapen (J:58731)
• the proximal part of the penial bone is smaller (J:58731)
• 1 of 18 females exhibit an abnormal fistula connecting the bladder and vaginal cavity (J:58731)
• stromal tissue surrounding the cervical canals is smaller and the cervical canal is greatly reduced in size (J:58731)
• the columnar-to-squamosal epithelial transition that characterizes mature cervical-vaginal tissue is positioned within uterine-like stroma rather than cervical tissue (J:58731)
• exhibit an anterior transformation of cervical tissue to a uterine stromal phenotype (J:58731)
• cervix is hypoplastic (J:58731)
• 5 of 18 females exhibit enlarged, fluid-filled uterine horns (J:58731)
• profoundly small vaginal cavity (J:58731)
(J:58731)

Mouse Models of Human Disease
OMIM IDRef(s)
Hand-Foot-Genital Syndrome; HFG 140000 J:58731