Mouse Genome Informatics
involves: C57BL/6J
phenotype observed in females
phenotype observed in males
N normal phenotype
• significantly slower to find the hidden platform when it was moved to a new location in the reverse trial of the Morris water maze test, indicating cognitive defects associated with acquiring or using new information in the face of exisiting information
• significantly more active throughout both light- and dark-phases when placed in a novel photocell cage than controls
• more reactive to handling than controls

nervous system
• fewer neurons in the globus pallidus, however the caudate/putamen, cerebral cortex, and corpus callosum were normal
• subthalamic nucleus is decreased in size and volume and contains fewer neurons

Mouse Models of Human Disease
Huntington Disease; HD 143100 J:25941