Mouse Genome Informatics
ht
    Htttm1Hay/Htt+
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• significantly slower to find the hidden platform when it was moved to a new location in the reverse trial of the Morris water maze test, indicating cognitive defects associated with acquiring or using new information in the face of exisiting information
• significantly more active throughout both light- and dark-phases when placed in a novel photocell cage than controls
• more reactive to handling than controls

nervous system
• fewer neurons in the globus pallidus, however the caudate/putamen, cerebral cortex, and corpus callosum were normal
• subthalamic nucleus is decreased in size and volume and contains fewer neurons

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:25941