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Phenotypes Associated with This Genotype
Genotype
MGI:3586839
Allelic
Composition
Htttm1Hay/Htt+
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm1Hay mutation (0 available); any Htt mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• significantly slower to find the hidden platform when it was moved to a new location in the reverse trial of the Morris water maze test, indicating cognitive defects associated with acquiring or using new information in the face of exisiting information (J:25941)
• significantly slower to find the hidden platform when it was moved to a new location in the reverse trial of the Morris water maze test, indicating cognitive defects associated with acquiring or using new information in the face of exisiting information (J:25941)
• significantly more active throughout both light- and dark-phases when placed in a novel photocell cage than controls (J:25941)
• significantly more active throughout both light- and dark-phases when placed in a novel photocell cage than controls (J:25941)
• more reactive to handling than controls (J:25941)
• more reactive to handling than controls (J:25941)

nervous system
• fewer neurons in the globus pallidus, however the caudate/putamen, cerebral cortex, and corpus callosum were normal (J:25941)
• fewer neurons in the globus pallidus, however the caudate/putamen, cerebral cortex, and corpus callosum were normal (J:25941)
• subthalamic nucleus is decreased in size and volume and contains fewer neurons (J:25941)
• subthalamic nucleus is decreased in size and volume and contains fewer neurons (J:25941)

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:25941


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory