Mouse Genome Informatics
hm
    Htttm1Hay/Htttm1Hay
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most die at around E7.5 and E8.5 and all are dead at E9.5
• most die at around E7.5 and E8.5 and all are dead at E9.5

embryogenesis
• gastrulation is disturbed
• embryos are small and underdeveloped at E7.5
• extraembryonic membranes are fragmented at E7.5 and a connection between the allanotis and the placenta does not form
• E8.5 embryos fail to neurulate, which leads to disorganization of embryos

growth/size
• embryos are small and underdeveloped at E7.5

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Huntington Disease; HD 143100 J:25941