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Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprdb-3J mutation (1 available); any Lepr mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype


• reduced lifespan, with 67% mortality between 6 and 14 months of age

• older mice exhibit sudden weight loss before death
• homozygotes accumulated excessive fat by 3 weeks of age
• by 6 months of age, mice weighed from 70-90 grams compared to 20-28 grams in controls


endocrine/exocrine glands
• necrosis of the exocrine, but not the endocrine pancreas was noted in aging animals
• less than 2-fold increase in the number of alpha cells per islet
• beta cell hyperplasia

• aged mice become hypoglycemic by 9 months of age
• mutant males, but not females, were transiently hyperglycemic between 2 and 4 months of age
• glucose levels declined thereafter
• plasma glucagon levels were increased by 3-fold in young mice and 5-fold in aged mice
• pancreatic glucagon content was only doubled compared to controls at 8 months of age
• at 5 months of age, plasma insulin levels were 30-fold greater in males, and 18-fold greater in females than in controls
• pancreatic insulin levels were 30-fold greater than controls at 8 months of age

reproductive system
• mice are sterile

digestive/alimentary system
• necrosis of the exocrine, but not the endocrine pancreas was noted in aging animals

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:6337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory