Mouse Genome Informatics
hm
    Leprdb-3J/Leprdb-3J
129P3/J-Leprdb-3J/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Leprdb-3J/Leprdb-3J

mortality/aging
• reduced lifespan, with 67% mortality between 6 and 14 months of age

growth/size
• older mice exhibit sudden weight loss before death
• homozygotes accumulated excessive fat by 3 weeks of age
• by 6 months of age, mice weighed from 70-90 grams compared to 20-28 grams in controls

behavior/neurological

endocrine/exocrine glands
• necrosis of the exocrine, but not the endocrine pancreas was noted in aging animals
• less than 2-fold increase in the number of alpha cells per islet
• beta cell hyperplasia

homeostasis/metabolism
• aged mice become hypoglycemic by 9 months of age
• glucose levels declined thereafter (J:6337)
• mutant males, but not females, were transiently hyperglycemic between 2 and 4 months of age (J:6337)
• plasma glucagon levels were increased by 3-fold in young mice and 5-fold in aged mice
• pancreatic glucagon content was only doubled compared to controls at 8 months of age
• at 5 months of age, plasma insulin levels were 30-fold greater in males, and 18-fold greater in females than in controls
• pancreatic insulin levels were 30-fold greater than controls at 8 months of age

reproductive system
• mice are sterile

digestive/alimentary system
• necrosis of the exocrine, but not the endocrine pancreas was noted in aging animals

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:6337